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- Randomized, placebo-controlled trials of the glucagon-like peptide-1 (GLP-1) receptor agonists have provided strong ...
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Most recent ADA 2025 guidelines emphasize: 1. Individualized first-line therapy Metformin is no longer mandatory first-line; initial therapy may start with SGLT2i or GLP-1 RA depending on comorbidities (ASCVD, CKD, HF,
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