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NNMT is a routing enzyme, not just a label. In NAD+ biology, nicotinamide can be recycled through salvage chemistry or methylated by NNMT using S-adenosylmethionine (SAM), yielding 1-MNA and SAH. 5-Amino-1MQ is

Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity | ACS Chemical Biology

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